Negative Effects of Dental Acne DrugsOral acne drugs treat the condition from within your body by subduing hormones that promote oil manufacturing. These include anti-biotics such as tetracycline (Tetracin, Tetracap) and minocycline (Solodyn, Minocin) and the pill called spironolactone (Aldactone).Some dental medications are offered over-the-counte